1. This tumor on the foot of a 25-year old boy is positive for Mart-1 and HMB45. Which one of the following additional tests is appropriate for narrowing the diagnosis?
A. Immunohistochemistry for S100
B. FISH with break-apart probe for Ewing gene
C. Immunohistochemistry for MITF
D. FISH with break-apart probe for SYT gene
2. What is the best diagnosis for this lesion based on histology?
A. Interstitial pattern of granuloma annulare
B. Metastatic breast carcinoma
C. Dermatofibroma
D. Nephrogenic systemic fibrosis
3. Based on histology the best diagnosis for this case is:
A. Discoid lupus
B. Subacute cutaneous lupus
C. Dermatomyositis
D. Tumid lupus
4. The disease depicted here is caused by a defect in the processing of which molecule?
A. Laminin
B. Profilaggrin
C. Colagen VII
D. Collagen XVII
5. Which one of the following entities represents the most likely diagnosis for this case?
A. Morphea
B. Nephrogenic systemic fibrosis
C. Scleredema
D. Keloid scar
6. Based on histology the best diagnosis for this case is:
A. Angiosarcoma
B. Kaposi sarcoma
C. Aneurismal dermatofibroma
D. Dermatofibrosarcoma protruberans
7. This is an example of:
A. Epithelioid blue nevus
B. Cellular blue nevus
C. Desmoplastic Spitz nevus
D. Pigmented spindle cell nevus of Reed
8. A 48 year old male presents with a red plaque present since childhood that underwent recent growth. By immunohistochemistry the lesional cells are positive for D2-40 and negative for HHV8. What is the best diagnosis?
A. Kaposi sarcoma
B. Benign lymphangioendothelioma
C. Well-differentiated angiosarcoma
D. Lobular capillary hemangioma
9. This cutaneous lesion may be associated with all of the following except:
A. Cardiac myxoma
B. Spotty pigmentation
C. Cushing’s syndrome
D. Neurofibroma
10. A 2-month infant developed a rash with a periorificial and acral location. Biopsy confirmed a diagnosis of:
A. Acrodermatitis enteropatica
B. Erythema multiforme
C. Drug eruption
D. Scurvy
11. A 45 year old male with a 1-year history of bone marrow transplant develops skin hardening of the trunk and proximal extremities. The biopsy is diagnostic of:
A. Morphea
B. Chronic graft versus host disease
C. Nephrogenic systemic fibrosis
D. Scleroderma
12. A 51 year old male presents with a flesh colored nodule on the face. Based on histology the best diagnosis for this case is:
A. Basal cell carcinoma
B. Sebaceoma
C. Sebaceous adenoma
D. Sebaceous carcinoma
13. Based on histology the best diagnosis for this case is:
A. Discoid lupus
B. Subacute cutaneous lupus
C. Dermatomyositis
D. Tumid lupus
14. A 38 year old female presents with subcutaneous nodules involving the proximal lower extremities. What is the best diagnosis?
A. Erythema nodosum
B. Erythema induratum
C. Lupus panniculitis
D. Pancreatic panniculitis
15. Based on histology the best diagnosis for this case is:
A. Amelanotic sclerosing blue nevus
B. Dermatofibroma
C. Scar
D. Desmoplastic melanoma
16. A 29 year old female presents with a 1.5 cm bluish nodule on the abdomen that reportedly has been bleeding. The biopsy is compatible with:
A. Metastatic colo-rectal adenocarcinoma
B. Cutaneous endometriosis
C. Microcystic adnexal carcinoma
D. Metastatic serous carcinoma of the ovary
17. A 65 year old female presents with a 4 cm nodule on the scalp. What is the best diagnosis?
A. Tricholemmal cyst
B. Proliferating tricholemmal cyst
C. Squamous cell carcinoma
D. HPV-related epidermal cyst
18. Based on histology the best diagnosis for this case is:
A. Pemphigus foliaceous
B. Darier disease
C. Grover's disease
D. Haley-Hailey disease
19. A 45 year old male with a prior biopsy diagnosed as melanocytic nevus presents with a dark macule at the site of the prior biopsy. The best diagnosis is:
A. Evolving melanoma in situ.
B. Invasive melanoma arising in an incompletely excised nevus.
C. Recurrent or persistent melanocytic nevus
D. Nevoid melanoma
20. Based on histology the best diagnosis for this case is:
A. Intradermal melanocytic nevus
B. Urticaria pigmentosa
C. Granular cell tumor
D. Telangiectasia macularis eruptiva perstans
21. A 22-year-old female presents with a 1.1 cm black colored nodule on her right buttock. The best diagnosis is:
A. Cellular blue nevus.
B. Clear cell sarcoma.
C. Desmoplastic melanoma.
D. Malignant blue nevus.
22. A 10-day old female infant presents with vesiculo-bullous lesions in a linear arrangement on the extremities and trunk. Biopsy confirms a diagnosis of:
A. Linear IgA disease
B. Incontinentia pigmenti
C. Erythema toxicum neonatorum
D. Transient neonatal pustular melanosis
23. A 45 year old male undergoing treatment for acute myeloid leukemia presents with a maculo-papular eruption. The best diagnosis is:
A. Granulomatous drug eruption
B. Intersitital granulomma annulare
C. Atypical mycobacterial infection
D. Leukemia cutis
24. The histology shown here is best diagnosed as:
A. Atypical fibroxanthoma
B. Malignant fibrous histiocytoma
C. Dermatofibrosarcoma protruberans
D. Dermatofibroma
25. What is the best imunohistochemical stain to help diagnose this tumor?
A. Tyrosinase
B. Mart-1
C. HMB45
D. S100
26. The majority of lesional cells in this tumor are positive for CD20 and negative for CD10 and CD3. The best diagnosis is:
A. Mycosis fungoides with large cell transformation
B. Diffuse large B-cell lymphoma
C. Follicular lymphoma
D. Extranodal marginal zone lymphoma
27. A 41 year old female presents with numerous macules and papules with a central scale. The best diagnosis is:
A. Mycosis fungoides
B. Pityriasis lichenoides chronica
C. Lichen planus
D. Guttate psoriasis
28. The histology shown here is best diagnosed as:
A. Melanoma in situ
B. Squamous cell carcinoma
C. Sebaceous carcinoma
D. Paget’s disease
29. An 18-year-old male presents with a pedunculated tumor inside antihelix of right year. Patient has had multiple surgeries since childhood to remove similar lesions from head & neck and extremities. What is the best diagnosis?
A. Amyloidosis
B. Juvenile hyaline fibromatosis
C. Infantile systemic hyalinosis
D. Nuchal fibroma
30. A 19 month-old male presents with a 6.7 x 4 cm brown plaque with central hypertrichosis on the right arm present at birth. Clinical diagnosis is that of a congenital nevus and a staged excision procedure is performed. What is the best diagnosis?
A. Melanoma in situ arising in a congenital nevus
B. Invasive melanoma arising in a congenital nevus
B. Congenital nevus with pagetoid spread
C. Atypical junctional melanocytic proliferation arising in a congenital nevus
Self Assesment Course I
